Soho Flordis International


For relief of premenstrual symptoms


Premular is a different way to manage symptoms of premenstrual syndrome (PMS).

Premular contains the specialised extract of Vitex agnus-castus Ze 440 which has been specifically researched in PMS.

Premular’s Ze 440 has been clinically proven to help relieve a broad range of PMS symptoms including irritability, altered mood, headache, bloating and breast pain and tenderness.1-3 Premular has also been shown to help maintain a healthy hormonal balance and regulate a healthy menstrual cycle.1-4

Always read the label. Contains lactose. Use only as directed. If symptoms persist, talk to your health professional.

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Premular® with specific extract Ze 440 has been shown to:

Provide multiple PMS symptom relief

Provide multiple PMS symptom relief

Including breast soreness, mood alterations, irritability, headaches and bloating.1-3

Provide sustained symptom relief

Provide sustained symptom relief

Sustained relief of PMS symptoms shown over time2

Help have a regular period

Help have a regular period

Relieves  menstrual cycle irregularities4

Research & Evidence

Premular: Key Ingredient

Premular contains an exclusive extract from the plant, Vitex agnus-castus, also known as chaste tree. The specific extract used in Premular – known as Ze 440 – has been researched in multiple clinical studies to  relieve PMS symptoms and menstrual irregularities.1-4

More about Vitex agnus-castus
trials & studies
Vitex agnus-castus Ze 440
Majority of women reported an over 50% improvement in PMS symptoms 1

Food for thought: Did you know that 70-90% of women may experience at least one symptom of PMS? Find out more about how Premular can help relieve premenstrual symptoms.

Our Source to Patient philosophy

Why are the details important?


The finer details of our medicines help ensure that you can feel confident that you are taking a reliable healthcare product. What you see in clinical studies is what you get in our products.

Find out how we bring you reliable medicines

Using Premular

Recommended dosage & directions


Adults and adolescents: take 1 tablet in the morning, preferably with food.

For best results take Premular for a minimum of 3 months, or as recommended by your health professional.

Vegetarian friendly formula. Premular contains no added gluten, wheat, yeast, soy or artificial colours or sweeteners. Premular tablets contain a small amount of lactose (40mg per tablet).

Your health professional can help you decide whether Premular is right for you. It is always best to discuss all of your symptoms with your health professional to determine whether Premular is a suitable option for you and how to use it.

Premular is well tolerated based on clinical research and years of worldwide use.

There are no known reported interactions between Premular (Ze 440) and other medicines. However, due to a potential hormonal effect if you are taking the oral contraceptive pill, it is important that you talk to you health professional before taking Premular.

Always read the label. Contains lactose. Use only as directed. If symptoms persist consult your healthcare professional.

Active ingredient
Chaste tree (Vitex agnus-castus)

Each Premular tablet contains:

Vitex agnus-castus Ze 440 extract 20mg equivalent to dry fruit 180mg


Premular is a natural medicine that has been proven to relieve the symptoms of PMS in clinical research.1-4 It contains a particular extract from the fruit of Vitex agnus-castus, called Ze 440. This specific extract Ze 440 and optimal dose has been tested in placebo-controlled clinical trials, so you can be sure that Premular has demonstrated relief of PMS symptoms.


Natural medicines can vary considerably depending on the species of plant chosen, the way it’s grown and harvested, and the extraction and production process. So it’s essential to ensure the product you receive is the same as that shown in clinical studies to relieve PMS symptoms.

The minimum recommended period is 3 months. However, depending on the condition and symptoms, Premular may be continued long term under the recommendation and guidance of your healthcare professional.

There are no known reported interactions between Premular and other medications.  However, if you are taking the oral contraceptive pill or other prescription medication, it is important that you talk to you healthcare professional before taking Premular.

Premular is not indicated for use during pregnancy or while breastfeeding. Although there are no reported safety concerns, there are no published studies to establish safety for the use of Premular during pregnancy or while breastfeeding. It is important to speak with a healthcare professional if you have specific questions or concerns. 

Premular is indicated for use in adults and adolescents with PMS symptoms. It is not recommended for use in children under 12 years.

It is important to discuss this with your healthcare professional, including the anaesthetist and surgeon.

Yes. Premular contains a very small amount of lactose (40 mg) in each tablet.

Premular has no known adverse effects on the ability to drive and operate machinery.  

Premular is available from pharmacies, selected health food stores and natural health practitioners. If you go to the Where to buy button above and follow the instructions, you will be able to find a list of practitioners and pharmacies in your area that either stock Premular or will know how to order Premular. Even if your local pharmacy is not on the list, they will be able to order it in for you. 



  1. Schellenberg R, et al. BMJ 2001;322:134-137.  Funded by Max Zeller Soehne AG.
  2. Berger D, et al., Arch Gynecol Obstet 2000;264:150-153.
  3. Schellenberg R, et al., Phytomedicine 2012; pii: S0944-7113(12)00280-2.  Funded by Max Zeller Soehne AG.4. Eltbogen R, et al. J Gynäkol Endokrinol 2015; 25(2):10-15.
  4. Tschudin S, et al., Arch Womens Ment Health 2010;13(6):485-494.
  5. Joshi JV, et al., J Midlife Health 2010;1(1):30-34.

Premular® is a registered trademark of Max Zeller Söhne AG.


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