Soho Flordis International

Valerian and Hops (Valeriana officinalis & Humulus lupulus Ze 91019)

Herbal sleep remedy

Valerian and Hops have a long history of helping provide relief of sleeplessness. 

Both Valeriana officinalis and Humulus lupulus have a long history of helping provide relief of sleeplessness.

 

In ReDormin Forte, two specific standardised extracts from Valeriana officinalis and Humulus lupulus are combined to create an exclusive formula, called Ze 91019 that is clinically researched to help improve the quality of sleep and restore healthy sleep patterns in 2 weeks.1

Discover more about the Ze 91019 formula used in Flordis ReDormin Forte, how it can work, and the key studies that support its benefits.

Always read the label, use only as directed. If symptoms persist consult your healthcare professional.

Valeriana officinalis and Humulus lupulus in history

Hops is a perennial vine native to temperate zones of North America, Europe and Asia, with a long history of use in North American indigenous medicine, Ayurveda and Chinese medicine systems. 2  

 

Valerian is a perennial plant native to subpolar Europe and Asia. The sedative effects of Valerian were first recognized over 2000 years ago in Ancient Greece. Its name is derived from the Latin word valere, which means “to be strong, be well”. Valerian is a flowering plant whose roots are used to make the extracts.3

Although Hops and Valerian have reported their own benefits, their synergistic combination has demonstrated significant benefit for the relief of sleeplessness.

 

The specialised combination of Ze 91019 used in ReDormin Forte is well researched and has been the choice of millions of people worldwide.

Valeriana officinalis and Humulus lupulus in history

The specific combination used in ReDormin Forte: Ze 91019

Ze 91019 is the specific combination of Valeriana officinalis and Humulus lupulus used in Flordis ReDormin Forte. Thanks to a careful and complex production process, the Ze 91019 extract can consistently contain the same composition and amount of active components, making it possible to investigate the efficacy of this fixed combination in clinical studies.

The beneficial effect of Ze 91019 is based on over 10 years of clinical research.1,4-7

Results from clinical studies suggests that Ze 91019 can help people with sleeping difficulties to:1,4-7

  • Fall asleep faster

  • Stay asleep longer

  • Restore healthy sleep patterns in 2 weeks

  • Improve sleep quality

  • Wake refreshed

The specific combination used in ReDormin Forte: Ze 91019

Research on how Ze 91019 works

Preclinical studies suggest that Ze91019 in ReDormin forte may work by acting on receptors of melatonin and adenosine.

Sleep regulation is a complex area of study. There are two underlying cycles that are believed to constitute normal sleep structure:

  • Circadian rhythm, or more commonly known as your internal body clock, is responsible for your sleep/wake cycle. 8,9

  • Homeostatic process is responsible for maintaining a constant and balanced internal environment for your body that helps you to get to sleep and stay asleep throughout the night 8,9

Pre-clinical studies suggest that Ze 91019 can positively affect both cycles through its action on biochemical pathways in the body involving:

  • Melatonin, a hormone involved in regulating circadian sleep rhythms
  • Adenosine, a neurotransmitter that typically accumulates throughout waking periods that promotes sleep and inhibits arousal

The two extracts that make up the fixed extract of Ze 91019 are:

  • Ze 919 (extract from Humulus lupulus): studies suggest it may act on receptors for melatonin, which can influence the body’s circadian sleep rhythms9,10
  • Ze 911 (extract from Valeriana officinalis): studies suggest it may act on adenosine receptors, which can promote sleep onset by decreasing arousal9,10

 

Research on how Ze 91019 works

Ze 91019 in clinical studies

More than 10 years of research conducted with Ze 91019, involving more than 3600 participants.1,4-7 The below table highlights some key clinical studies conducted on Ze 91019.

Koetter et al., 2007 4

30 patients with sleep issues studied over 4 weeks

Significantly superior

vs. placebo for:

  • Time taken to fall asleep

Additionally: General improvement observed in quality of sleep and time spent in deeper sleep stages

Lataster et al., 1996 5

3447 patients with sleep disruption
studied over 4-6 weeks

Improvement increased 3-fold

of:

  • number of people who were able to stay asleep through the night without waking or waking only once
Notter et al., 2003 6

144 patients with sleeplessness
studied over 4 weeks

Improvement

of:

  • Severity of sleep issues, including mild-moderate insomnia Time taken to fall asleep and sleep duration Sleep issues associated with short-term waking Well-being and performance during the day*

*When sleep duration was increased on average by an hour

Fussel et al., 2000 1

30 patients with mild-moderate insomnia
studied over 2 weeks

Improvement

of:

  • Natural sleep patterns Time taken to fall asleep Time spent in deeper restorative stages of sleep Sleep quality and efficiency Total sleep vs. wake time 4 out of 5 people reported waking feeling refreshed 87% of patients reported sustained sleep benefits 4 weeks after finishing Ze 91019

Always read the label. Follow the directions for use. If symptoms persist, talk to your health professional.

Flordis Difference

ReDormin Forte with Ze 91019 vs. valerian and hops  

 

There may be several products on the market labelled as containing a particular ingredient – such as Valeriana officinalis and Humulus lupulus. So what makes the Ze 91019 extract in ReDormin Forte different?

 

Natural healthcare products can vary considerably depending on how they are produced. The specific Ze 91019 combination used in ReDormin Forte is produced using a meticulous process with careful consideration and control at every stage of creation. This helps ensure that the natural medicine you are getting contains the exact ingredient, in the exact amounts demonstrated in clinical research to relieve sleeplessness. That’s the Flordis difference.  

Ze 91019 in ReDormin Forte: A Summary

Consistent quality

Rigorous quality control processes and extensive testing help ensure that the Ze 91019 combination can provide the desired health outcomes demonstrated in clinical studies.

Over 10 years of research

Numerous clinical studies demonstrating relief of sleeplessness 1,4-7

Well tolerated

With no known morning drowsiness or rebound insomnia recorded based on clinical research and worldwide surveillance reports.

Recommended to millions world wide

Recommended and chosen by millions of people worldwide for over 20 years

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Our source to patient philosophy

We make sure our natural medicines are consistent.

 

Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products
References

1. Fussel A, et al., Eur J Med Res 2000;5:385-390.
2. Herbal Medicine: Expanded Commission E Monographs: Hops. American Botanical Council. http://cms.herbalgram.org/expandedE/Hops.html Accessed October 2018
3. Herbal Medicine: Expanded Commission E Monographs: Valerian root. American Botanical Council. http://cms.herbalgram.org/expandedE/Valerianroot.html Accessed October 2018
4. Koetter U, et al., Phytopher Res 2007;21:847-851.
5. Lataster MJ, et al., Notabene Medici 1996;4:182-185.
6. Notter D, et al., Phytotherapy 2003;3:9-13.
7. Morin CM, et al., Sleep 2005;28(11):1307-1313.  Dr. Morin has received research support and consulting fees from Sanofi-Aventis, Takeda, Pfizer, Neurocrine, and Sepracor.
8. Brattström A. Wien Med Wochenschr 2007; 157/13-14:367-70.
9. Schellenberg R, et al., Plant Med 2004; 70:1-5.