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Urinary Tract Infections (UTIs) are prevalent, particularly in women, and contribute a significant burden to the individual and healthcare system. Currently antibiotics are the main treatment option for UTIs and are also used as a preventative strategy in managing recurrent infections. Overuse of antibiotics allows microbes to develop resistance, be less effective over time and common infections such are UTIs may carry increased risk of mortality and morbidity. This paper will explore the issues and limitations with prophylactic antibiotics to manage recurrent UTIs, such as side effects of treatment and antimicrobial resistance. Evidence for cranberry’s role in UTI prevention and possible mechanisms of action will also be detailed.