For the symptomatic relief of premenstrual syndrome (PMS)

Based on 347 reviews

Premular packshot

Is Premular right for you? Chaste tree flower

For a time each month are you feeling not quite yourself? Perhaps you are less tolerant, angry, and irritable? 

If this is happening before your period starts and you’re feeling back to feeling like your old self again once you begin to menstruate, you may be suffering from Premenstrual Syndrome (PMS). And you’re not alone.  It is estimated that 40% of women will be significantly affected by PMS symptoms at some time during their life and up to 7% will suffer severe symptoms The average age of onset is 26 years.1 

But the good news is that with Premular, there’s something you can do about it. 

Premular is an evidence-based natural medicine that is clinically proven to relieve a range of physical and mental PMS symptoms including irritability, anger, bloating, breast fullness, headache and mood and provides increasing and sustained relief over time.1-4 Premular is also well tolerated and its once-a-day dosing makes it convenient to take.


Where to buy

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The Premular Difference

Premular contains a specific extract of the Vitex agnus-castus (Chaste tree), the one that has been used in a number of clinical trials. This extract, referred to as Ze 440, is exclusive to Premular, which means Premular is a Vitex agnus-castus product that has demonstrated significant efficacy in clinical trials, including a double-blind placebo controlled study published in the British Medical Journal.2

One recent publication confirmed that the dose used in Premular is the optimal dose for the relief of PMS symptoms.3

Relief of symptoms: Three published Premular clinical trials suggest significant relief in PMS symptoms for women taking Premular over a 3-month period, and lasting for 3 cycles even after therapy has ceased.2,3

Premular tablets are easy to take and are well tolerated, with millions of doses recommended worldwide. Premular is manufactured in Switzerland according to proven production methods to help ensure you get a consistently reliable medicine, which is the same medicine used in clinical trials. Premular has also been assigned a ‘well established medicinal use status’ a status based on its history, evidence and excellent tolerability.5,6Learn more about Vitex agnus-castus >

Product details


Premular contains a clinically trialled extract (Ze 440) of the herb Vitex agnus-castus, also known as Chaste tree. Each tablet of Premular contains extract equivalent to dry Vitex agnus-castus fruit 180mg. Vitex agnus-castus has a long history of traditional use for hormonal conditions and menstrual complaints. Learn more about Vitex agnus-castus.


Directions for use

Recommended Dosage and Directions

Adults: 1 tablet per day

For best results take Premular for a minimum of 3 months. 


Premular has a documented safety profile and is well tolerated.


FAQs About Premular

Is Premular likely to have any side effects?

Premular is generally very well tolerated and not expected to cause unwanted side effects. However, in rare cases occasional itching of the skin may occur and, at the start of the dosage only, certain isolated premenstrual symptoms may be slightly increased. These symptoms should resolve without discontinuing Premular. If you are concerned you are experiencing side effects from Premular, it is important to speak with your healthcare practitioner.

Is Premular likely to interact with any medications?

There are no expected drug interactions with Premular. It is important to discuss taking Premular with a healthcare professional if you are on prescription medications.

Can Premular be used in pregnancy and lactation?

Due to the lack of menstrual cycle during pregnancy, Premular is not indicated for use during pregnancy or while breastfeeding. Moreover, there are no published studies to establish safety for the use of Premular during pregnancy or while breastfeeding. However, there is also no evidence for concern if a woman taking Premular falls pregnant. It is important to speak with a healthcare professional if you have specific questions or concerns.

Is Premular suitable for children and adolescents?

No, Premular is not recommended for women under the age of 18 years.

How does Premular differ to other chaste tree products?

Premular contains a clinically proven extract of Chaste tree (Vitex agnus-castus) referred to as Ze 440. Exclusive to Premular, Ze 440 has demonstrated efficacy in clinical trials, including a study suggesting Premular contains an optimal dose for the relief of a range of PMS symptoms.

When taking Premular, you can be confident you are receiving a consistent natural medicine that has been tested in clinical trials.

Consistency is important as there can be great natural variation in the extract used in Chaste tree products. Even if they appear to use the same active ingredients, they can differ due to the plant that is used, growing methods, harvesting processes and manufacturing methods. The outcomes of clinical studies for natural medicines may only apply to the product that has been examined in clinical trials.

How long should Premular be taken for?

The minimum recommended treatment period is 3 months. Depending on the condition and symptoms, Premular can be continued long term. It is important to speak with a healthcare professional if you have any questions about taking Premular.

When should I start taking Premular in my cycle?

Dosing should be started within the first few days of a menstrual cycle (ie within the first few days of menstrual bleeding) and continue throughout the month.

Is Premular gluten free?

Premular has no added gluten, wheat soy, sugar, yeast, salt, artificial colours or preservatives.

Does Premular contain lactose?

Yes, Premular contains a very small amount of lactose (40 mg) in each tablet.

Should Premular be stopped before surgery?

It is important to discuss this with your healthcare professional, including anaesthetist and surgeon.

Will Premular affect the ability to drive and operate machinery?

Premular tablets have no known adverse effects in these situations.

Where can I find Premular?

Premular is available from naturopaths, herbalists, other natural health practitioners, selected health food stores and pharmacies. If you go to the Where to buy button above and follow the instructions, you will be able to find a list of practitioners and pharmacies in your area that either stock Premular or will know how to order Premular. Even if your local pharmacy is not on the list, they will be able to order it in for you.

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Quality & Consistency

Flordis applies pharmaceutical grade processes to the development of natural medicines. This commitment to rigorous processes and to sourcing the highest quality ingredients results in a portfolio of premium natural medicines.

Clinical Research

The medicine you find in Flordis products is the specific medicine that has been used in clinical trials, which is one of the reasons you can feel confident about its effectiveness.


Driven by evidence and applying a quality-first approach to the development of our medicines, Australians enjoy the health benefits that millions have experienced worldwide.

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1. Lentz GM, et al (eds). Comprehensive Gynecolgy 6th Ed 2012. Elsevier Mosby. Chap 36 pp 797-803 2. Schellenberg R et al. BMJ 2001;322:134-137 3. Schellenberg R, et al. Phytomedicine. 2012; pii: S0944-7113(12)00280-2 4. Berger D et al Arch Gynecol Obstet 2000;264:150-153  5. Committee on Herbal Medicinal Products (HMPC). EMEA/HMPC/144003/2009 6. Committee on Herbal Medicinal Products (HMPC). EMA/HMPC/144006/2009 7. Dickerson LM, et al. Am Fam Phys. 2003;67:1743-52 

Some of this research was conducted using funding provided by Max Zeller Soehne AG, the manufacturer of this product.