Soho Flordis International

American cranberry (Vaccinium macrocarpon)

Urinary tract support

Cranberry or Vaccinium macrocarpon, has long been known for its beneficial effect in urinary tract health.

Vaccinium macrocarpon was first recognised for its urinary health benefits in the 1800s.1 Today, cranberry supplements are commonly used to help reduce the occurrence of medically diagnosed cystitis. 

 

Ellura contains a scientifically formulated extract of cranberry with a standardised dose of 36 mg of PACs in every capsule.  In clinical studies, Ellura has been shown to support urinary tract health and to help reduce the frequency of medically diagnosed cystitis in both adults and children. 3-5

 

Discover more about Ellura's scientifically formulated active ingredient and key studies that support its benefits. 

 

Vaccinium macrocarpon in history

Vaccinium macrocarpon, commonly known as American cranberry is native to North America and grown across tens of thousands of acres throughout the United States and Canada.6

Historically, cranberry has been used for a number of wide-ranging health benefits including digestive complaints but it's most known for its role in promoting urinary tract and bladder health.6

 

Cranberries are sometimes referred to as a “super food” because of their nutritional content, particularly because they naturally contain antioxidants. PACs are one of the antioxidant compounds found in cranberries that assists flushing the urinary tract when taken at the correct standardised dose. In order for PACs to have this therapeutic effect it is recommended to consume 36 mg of PACs. 2,7

Vaccinium macrocarpon in history

Specific cranberry extract used in Ellura

Cranberry supplements are not necessarily created equally. Different products can contain varying amounts of an active ingredient known as proanthocyanidins (PACs). In Ellura a specialised process is used to ensure 36 mg of PACs is in every capsule. This is the dose of PACs that has been researched and recommended worldwide to support urinary tract health.

The PACs contained in cranberry can be fragile, meaning they can be easily degraded by heat or oxidation. That’s why the production process is essential in preserving the concentration of PACs in the finished product.8 That’s why in Flordis Ellura a specialised process is used to ensure the recommended dose of 36 mg of PACs is in every capsule of Ellura.

 

In addition, it is suggested that before the DMAC* method was established as a PACs analysis method, the level of strength of any product could possibly be over- or under-estimated depending on how PAC content was measured.8,9

 

DMAC is a scientifically validated method that was created to standardise the cranberry industry worldwide to know just how much PACs is in each product. 8

 

In 2013, a study was conducted to test the PACs content of 11 different cranberry supplements using the DMAC method. The results in the chart below suggest that available cranberry supplements at the time had varying levels of PACs when tested using the DMAC method. While Ellura was found to meet the 36 mg recommended dose of PACs.10

 

Laboratory test showing PAC content of 11 Australian cranberry supplements

 

Clinical research has shown that the daily consumption of 36 mg of PACs from cranberry can help reduce the frequency of medically diagnosed cystitis.3-6 Therefore it is important to ensure the product you take has 36 mg of PACs in the dose so you can more feel more confident it will have the same results as in the research.

 

Ellura is a concentrated cranberry extract that is standardised to provide the recommended 36 mg of PACs in each one-a-day capsule.

 

*4-dimethylaminocinnamaldehyde (DMAC)

 

 

Specific cranberry extract used in Ellura

Research on how Ellura specific concentrated extract may work

The most common culprit of recurrent cystitis is a harmful bacteria called E. coli which can multiply and attach to the urinary tract wall.11 There is evidence to suggest that PACs in cranberry work by helping to prevent harmful E. coli bacteria from sticking to the urinary tract wall.2

Researchers propose a number of ways that PACs could prevent this bacterial adhesion.  One possible way is by the PACs binding to the tips of E.coli bacteria, preventing adhesion to the urinary tract wall which then allows the bacteria to be flushed out in the urine. 12

Research on how Ellura specific concentrated extract may work

Clinical studies on cranberry extracts with 36 mg PACs

The benefits of cranberry for urinary tract health are supported by both traditional and clinical evidence. A number of research studies including those featured in the table below have been conducted on cranberry concentrated extracts with the standardised recommended dose of 36mg PACs.2-5

Uberos et al., 2012 3

192 children^ with a history of recurrent cystitis
studied over 12 months*

Positive results

  • Is a viable option for helping to reduce the frequency of medically diagnosed cystitis

*0.2mL/kg of cranberry syrup (36 mg PACs)

^Aged 1 month - 13 years

Randomised, double-blind, Phase III study. 

Bianco et al., 2012 4

80 elderly females living in a nursing home
studied over 1 month*

Dose dependent trend toward decrease

  • harmful bacteria usually responsible for recurrent cystitis

*Cranberry capsules; 3x (108 mg PACs), 2x (72 mg PACs) or 1x (36 mg PACs) daily; or placebo daily

Pilot, randomised, double-blind placebo-controlled study. 

Botto et al., 2010 5

15 elderly patients
studied over 33 months*

Significant decrease

  • urine samples with harmful bacteria
  • rate of recurrent medically diagnosed cystitis symptoms

*the median time of treatment with Ellura (36 mg PACs)

Pilot open study.

Howell et al., 2010 2

32 adult female patients studied for 24 hours*

Significant results

vs. placebo for:

  • bacterial anti-adhesion activity in urine samples collected from participants^

*Cranberry capsules;18mg or 36 mg of PACs;  or placebo

^ measured ex vivo (not in the body)

Double-blind multicentric, placebo-controlled, randomised study. 

This medicine may not be right for you. Read the warnings before purchase. These can be found in the dosage and directions sections of the Ellura product web page.  Follow the directions for use. If symptoms persist, talk to your health professional.

Simply different

Cranberry vs. Ellura with 36 mg PACs  

 

Products with naturally sourced active ingredients can vary considerably depending on how they are produced. Ellura follows a meticulous production process with careful consideration to ensure a consistent form and quantity of PACs in every batch.

 

Ellura is made from the pure juice concentrate of the American cranberry. Based on years of research, a proprietary production process has been developed that removes the seeds, stems and skins of cranberry. This ensures consistently high levels of the active ingredient PACs. 36 mg of PACs is the recommended dose demonstrated to help to flush away harmful bacteria.

 

The Flordis Source to Patient philosophy helps to ensure that Ellura is:

  • High quality with the optimal amount of bioactive PACs
  • Consistently reliable, batch after batch
  • Researched in clinical studies

Ellura with 36 mg PACs: A Summary

36mg of PACs per capsule

Which is the amount of bioactive PACs that has been researched and recommended
worldwide. 2-5

Clinically researched

To support urinary tract and bladder health by helping flushing the urinary.2-5

Consistent Quality

Rigorous processes, quality controls and extensive testing help ensure that the concentrated cranberry extract is the same as that tested in clinical research.

Well tolerated and recommended worldwide

To support urinary tract health and reduce the frequency of medically diagnosed cystitis. 

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Our source to patient philosophy

We make sure our natural medicines are consistent.

 

Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products
References
  1. Braun, L & Cohen, M (eds). Herbs and Natural Supplements: An evidence-based guide. 2014; 138.
  2. Howell AB et al., BMC Infectious Diseases 2010:94:1-11.
  3. Uberos J et al., Open Access J of Clinical Trials 2012;4:31-38.  Funded by the Carlos III Institute of Health for Clinical Research, Madrid, Spain
  4. Bianco L et al., J Am Geriatr Soc 2012; 60:1180-1.
  5. Botto H & Neuzillet Y., Scand J of Urol and Nephrol 2010; 44: 165-8.
  6. World Health Organization. WHO monographs on selected medicinal plants Volume 4. World Health Organization. Geneva, 2009.
  7. Jepson RG et al., Cochrane Collaboration 2012; 10.  Funding for the 2012 update provided by the UK NHS NIHR.
  8. Prior RL et al., J Sci Food Agric 2010; 49:1270-1276.
  9. Standardized Testing Method for Cranberry Products.  Available: here. Accessed October 2018.
  10. Agrobio Laboratories, Report on proanthocyanidins of cranberry products in Australia, 2013.
  11. Mayo Clinic. Cystitis Overview available: here. Accessed October 2018.
  12. Foo et al., J Nat Prod 2000, 63:1225-1228.

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