Soho Flordis International

St John's wort (Hypericum perforatum)

Helps relieve stress and mild anxiety 

Ze 117, a specific extract of St. John’s wort is well-studied and recommended worldwide for helping to relieve mild anxiety and stress.1

Hypericum perforatum, commonly known as St. John’s wort, has long been recognised for its medicinal health benefits since Ancient Greece. Today St. John’s wort is well-studied and recommended worldwide for helping to relieve mild anxiety and stress.1

 

Because of this, there are many types of St. John’s wort preparations in the form of teas, tinctures, liquids, powders, tablets, and capsules. These are often made with varying production methods, which can result in different amounts of active components.

 

In Remotiv® a specific extract of Hypericum perforatum – called Ze 117 – is used. Remotiv with Ze 117 has been extensively researched in clinical studies and is used by millions worldwide to support a healthy mood.

 

Discover more about Ze 117 used in Remotiv and the key studies that support its benefits.

Hypericum perforatum in history

Hypericum perforatum, commonly known as St. John’s wort, is a commonly used herb for relief of stress, mild anxiety and mood-related symptoms. St. John’s wort is native to Europe, North Africa and western Asia.1

The value of St. John’s wort has been known for over 2000 years. Greek medical herbalists, such as Hippocrates, Galen and Dioscorides historically used this herb in various applications relating to nerve complaints.1

 

St. John’s wort continued to be used through the Middle Ages, however in the early 1500s, it was Paracelsus that exposed its benefits in supporting healthy mood and emotional balance.1 In the following centuries the use of St. John’s wort spread across Europe and other continents and became more widely used to help relieve mild anxiety, stress, and support a healthy mood.

Hypericum perforatum in history

The specific extract used in Remotiv: Ze 117

Ze 117 is the exclusive extract of Hypericum perforatum used in Remotiv. The specific extract is developed according to strictly controlled production methods with careful consideration at every stage of growing, cultivation, extraction and production. This helps to ensure that each batch of Remotiv is consistent with the next and with the natural medicine tested in clinical research for relief of mild anxiety and stress. 

Maintaining quality consistency in the production of Ze 117 helps ensure consistency in the amount and composition of important active constituents from one batch to the next. 

 

The batch-to-batch consistency of Ze 117 can be demonstrated in the diagram below. The graph shows how the amount of one single active component of St. John’s wort, known as Hyperforin, can vary between five different batches of the same product. However, Ze 117 was able to demonstrate batch-to-batch consistency.

 

 

Each Remotiv tablet contains:

Extract equivalent to dry Hypericum perforatum herb top flowering 1.375 g (harvested during flowering period) = 250 mg of St John’s wort extract  Ze 117

 

The therapeutic benefits of Ze 117 are based on multiple clinical studies involving over 1000 people.2-5 This research has shown that Ze 117  can help to support a healthy mood and  relieve:

  • Stress
  • Mild anxiety
  • Nervous tension
  • Restlessness / unrest
  • Irritability
The specific extract used in Remotiv: Ze 117

Research on how Ze 117 works

It is not fully understood how the Ze 117 extract of Hypericum perforatum works, however pre-clinical evidence suggests that it may have effects on three of the key neurotransmitters (serotonin, noradrenaline and dopamine) in the brain that are linked to mood and feelings of stress and nervous tension.  

The preclinical studies suggest that Ze 117 can have effects on both downregulation of receptors and re-uptake inhibition of serotonin, noradrenaline and dopamine.7,8 'What this means is that it may affect key neurotransmitters in the brain linked to mood and feelings of stress and nervous tension.

 

The studies also suggest that the therapeutic activity of Ze 117 is due to the overall effect of the entire Ze 117 extract which is stronger than the effect of single constituents of the extract. 

Research on how Ze 117 works

Ze 117 in clinical studies

Ze 117 has been researched in multiple clinical studies, including a study published in the British Medical Journal that was a one-year study that showed continued relief with good tolerability. 5  

Schrader Et al., 1998 2

162 patients with mood-related symptoms
studied over 6 weeks*

Significant improvement

vs. placebo of:

  • Mood-related symptoms

And showed good tolerability

*2 tablets of Ze 117 250mg

Schrader 2000 3

240 patients with mood-related symptoms
studied over 6 weeks*

Positive results

  • Improved mood-related symptoms Good tolerability

*2 tablets of Ze 117 250mg

Woelk 2000 Et al., 4

324 patients with mood-related symptoms
studied over 6 weeks*

Positive results

  • Improved mood-related symptoms Improved feelings of mild anxiety Good tolerability

*2 tablets of Ze 117 250mg

Brattström 2009 5

440 patients with mood-related symptoms
studied over 1 year

Improvement

  • Mood-related symptoms And showed: Good tolerability

*2 tablets of Ze 117 250mg

This medicine may not be right for you. Read the warnings before purchase. These can be found in the dosage section of the Remotiv web page.  Follow the directions for use. If symptoms persist, worsen or change unexpectedly, talk to your health professional.

Flordis Difference

There may be several products on the market labeled as containing a particular ingredient – such as St. John’s wort. So what makes Ze 117 in Remotiv different?

 

Natural healthcare products can vary considerably depending on how they are produced. Ze 117 is a specific extract of St John’s wort made using highly controlled production methods with careful consideration at every stage of creation.

 

That means, you can be sure that the product you are getting contains the same specific extract demonstrated in clinical studies to help relieve stress, mild anxiety and support a healthy mood.  

Remotiv with Ze 117: A Summary

Consistent quality

Rigorous quality control processes and extensive testing to help ensure that the Ze 117 extract can provide the desired health outcomes demonstrated by clinical studies

Backed by years of research

To support a healthy mood and emotional balance

Helps relieve stress & mild anxiety

and ease feelings of nervous tension restlessness and irritability

Well tolerated and used worldwide

By millions of people for over 20 years.

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Our source to patient philosophy

We make sure our natural medicines are consistent.

 

Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products
References
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin: American Botanical Council; 1998: 395-366
  2. Schrader E, et al., Human Psychopharmacology 1998; 13:163-169.
  3. Schrader E. Int Clin Psychopharma 2000; 15:61-68.  All participating investigators were funded by the German medical insurance system.
  4. Woelk H, et al., BMJ 2000; 321:536-539.  Bayer AG sponsored the study through the clinical research organisation Beromed, Berlin, Germany.
  5. Brattström A. J Phymed 2009; 16:277-283.
  6. Wurglics M, et al., J Am Pharm Assoc 2001;41(4):560-566.
  7. Kientsch U, et al., Pharmacopsychiatry 2001; 34 Suppl1: 56-60.  This work was supported by a research grant from Zeller Medical AG., Romanshorn, Switzerland.
  8. Ruedeberg C, et al., Phytother Res 2010; 24:249-251.  This work was supported by a research grant from Max Zeller Soehne AG, Romanshorn, Switzerland.