SFI Health

Brahmi (Bacopa monnieri CDRI 08)

Research Overview

Discover the clinical evidence for Bacopa monnieri CDRI 08.

Bacopa monnieri, commonly known as Brahmi or Bacopa is a medicinal herb, used for generations in Ayurvedic medicine for supporting memory, brain health, concentration and learning function.


Explore the research behind a specific standardised extract of Bacopa monnieri, known as CDRI 08 which has been extensively researched for over 50 years* to support cognitive health.1-6

The specific extract CDRI 08

CDRI 08 is a specific Bacopa monnieri extract. It was first researched in the 1970s by the Indian government’s Central Drug Research Institute, and has been the subject of research for more than 50 years* to support its benefits for cognitive health.

The memory supporting effect of CDRI 08 is based on numerous clinical trials. Results from these clinical trials suggest that CDRI 08 helps to:1-6

  • Maintain healthy cognitive function
  • Improve working memory
  • Assist in learning retention
  • Assist with concentration and focus as well as keeping to task and maintaining attention span
  • Can be beneficial during times of stress or mild anxiety
The specific extract CDRI 08

Research on how CDRI 08 works

Pre-clinical studies suggest that Bacopa monnieri  in CDRI 08 can help support brain function in several different ways.

Antioxidant effects to help support against oxidative stress 8,9


Regulation of communication between brain cells and activity associated with learning and memory10


Affecting neurotransmitter systems involved with memory related processes11,12


Adaptogenic effects that can help support the body in times of physical and mental stress13

Research on how CDRI 08 works

CDRI 08 in cognitive health: clinical trials

The specific CDRI 08 extract of Bacopa monnieri has been researched in multiple randomised controlled trials demonstrating that it can help improve cognitive function and is well tolerated at the recommended dose.1-6  The table below covers a selection of key clinical studies on CDRI 08.

Stough, et al. 20011

46 healthy adults (18-60)
studied over 12 weeks

Significant improvement

vs. placebo for:

  • speed of visual information processing
  • learning rate
  • memory consolidation
  • forgetting rate
  • mild state of anxiety

Randomised, souble-blind, placebo controlled, independent group study.

Stough 20082

107 healthy adults
studied over 90 days

Significant improvement

vs. placebo for:

  • working memory
  • mistakes in visual information processing

There was a trend toward improved cognitive functioning areas of attention and working memory. KeenMind was well tolerated. 

Randomised, double-blind, placebo controlled, independent group study. 

Downey 20136

24 healthy adults (18-56 years)
studied over 2 hours

Positive Effect

vs. placebo for:

  • improved cognitive performance, including:
  • information processing, decision making time, and attention or freedom from distractibility

Randomised, double-blind, placebo controlled, crossover design study. 

Roodenrys 2002 3

76 healthy adults
studied over 3 months

Significant improvement

vs. placebo for:

  • retention of new information
Raghav 2006 4

40 adults with memory concerns
studied over 12 weeks

Significant improvement

vs. placebo for:

  • mental control
  • logical memory
  • paired associated learning
Benson 2014 5

17 healthy adults
studied over 2 hours

Positive Effect

vs. placebo for:

  • acute cognitive function
  • mood
  • stress

Always read the label. Follow the directions for use. If symptoms persist talk to your health professional.

Brahmi in history

Bacopa monnieri, also known as Brahmi, is a small creeping herb found throughout the Indian subcontinent.

It has been used in Ayurvedic medicine for almost 3000 years.Throughout this time, it has been associated with a variety of health benefits including heightened learning capacity, promoting memory and concentration, as a nerve tonic and to support cardiovascular health. 7 

It is the memory and learning effects of Bacopa that have attracted the most attention in the last few decades and, in doing so, have become the subject of much clinical research.

CDRI 08 is the specific Bacopa monnieri extract that was first researched in the 1970s by the Indian government’s Central Drug Research Institute, and has been the subject of research for more than 50 years* to support its benefits for cognitive health.

CDRI 08: A Summary

Consistent quality

Through our rigorous processes, quality controls and extensive testing we help ensure that every batch of Bacopa CDRI 08 can provide the desired health outcomes demonstrated by clinical studies.

50 years of research

Beginning in 1974* by the Central Drug Research Institute (CDRI) in India and more recently in Australia.15

6 Clinical trials

Bacopa CDRI 08 clinical studies support its role in improving cognitive function1-6

Well tolerated and used worldwide

to support cognitive health, memory, concentration and learning function.

Available Resources

The Importance of Plant Extracts

The Importance of Plant Extracts

Lifestyle insight

Not all medicines with naturally sourced active ingredients are created equal – that's why Flordis believes it's important to consider the specific herbal extract, not just herb names.

Integrative Medicine & Flordis

Our source to patient philosophy

We make sure our natural medicines are consistent.


Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products
  1. Stough C, et al., Psychopharmacology (Berl) 2001;156(4):481-484.
  2. Stough C, et al., Phytother Res 2008;22(12):1629-634.
  3. Roodenrys S, et al., Neuropsychopharmacology 2002;27(2):279-281.
  4. Raghav S, et al., Indian J Psychiatry 2006;48(4):238-242.
  5. Benson S, et al., Phytother Res 2014;28(4):551-559.  Funded by Soho Flordis International (SFI).
  6. Downey LA, et al., Phytother Res 2013;27(9):1407-1413.  Funded by Soho Flordis International (SFI).
  7. Singh HK. Nutrients 2013;5(2):478-497.
  8. Simpson et al.,  Evid Based Complement Alternat Med 2015; Article ID 615384.  The authors conduct studies on Bacopa monnieri (CDRI08) that are funded by SOHO Flordis International (SFI). Tamara Simpson is funded by an Australian Postgraduate Research Award to conduct this research. Professor Stough’s work on Bacopa monnieri (CDR108) is funded by a large grant from the Australian Research Council (ARC) DP1093825.
  9. Bhattacharya SK et al., Phytother. Res. 2000;14: 174–179.
  10. Mondal P, Trigun SK., Evid Based Complement Alternat Med 2015; Article ID 535013.
  11. Das et al., Pharmacol Biochem Behav 2002; 73 (4):893-900.
  12. Rajan et al., Neurochem Res 2011; 36 (11):2136-44 [S14-0165].
  13. Rai D, et al., Pharmacol Biochem Behav 2003;75:823-830.

* The extract CDRI 08 was initially researched in 1974 and is still the subject of ongoing clinical research.

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