Soho Flordis International

Black cohosh (Actaea racemosa)

Proven relief from menopause symptoms

Ze 450 is a clinically proven extract of Actaea racemosa, that has been shown to significantly relieve a range of menopause symptoms 7-9

Actaea racemosa has been used for the relief of menopause symptoms for many years, providing an evidence-based option derived from nature for women going through this natural lifestage.


In the Femular range, a specific extract of Actaea racemosa (Black cohosh) is used, called Ze 450. Over the past decade, Femular has been extensively researched to provide relief of menopause symptoms and to ease the discomfort you may experience throughout menopause.


Discover more about the specific Ze 450 extract used in Femular and the key studies that support its benefits.

Actaea racemosa in history

Actaea racemosa, or Cimicifuga racemosa or Black cohosh as it is also called, is a perennial herb, native to North America. 1  

Traditionally, Actaea racemosa was used for the treatment of various concerns in women’s reproductive and gynaecological health, and also the urinary and musculoskeletal systems.  

In the 1950s, it gained popularity among European women as a herbal medicine for menopausal complaints. 2-3


Today, there are different preparations and forms of Actaea racemosa widely used by women all around the world who are looking for a way to address hot flushes and other symptoms of menopause.

Actaea racemosa in history

The specific Ze 450 extract used in Femular

Ze 450 is the specific extract of Actaea racemosa used in the Femular range. The exclusive extract is manufactured according to strictly controlled production methods with careful consideration at every stage of growing, cultivation, extraction and production. This helps to ensure that each batch of Femular is consistent with the next and with the natural medicine tested in clinical research for menopausal symptom relief.  

Each Femular tablet contains:

Extract equivalent to dry Actaea racemosa 42.25 mg = Ze 450 6.5 mg


Each Femular Forte tablet contains:

Extract equivalent to dry Actaea racemosa 84.5 mg = Ze 450 13 mg


The beneficial effect of Ze 450 is based on a number of clinical trials and studies in women throughout all stages of menopause. Results from these studies prove that Femular products can relieve menopausal symptoms including:7-9


  • Hot flushes
  • Night sweats
  • Sleep disturbances
  • Nervous tension
  • Irritability
  • Headache*
  • Temporary feelings of sadness*
  • Fatigue*
  • Joint pain*

Femular (1 tablet dose) is suitable for mild to moderate symptoms of menopause while Femular Forte (1 tablet dose) or Femular (2 tablet dose) is more suitable for those who have moderate to severe menopausal symptoms.


*1 x Femular Forte (Ze 450 13 mg)  or 2 x Femular tablets (Ze 450 6.5 mg)

The specific Ze 450 extract used in Femular

Research on how Ze 450 extract works

It is not fully understood how the Ze 450 extract of Actaea racemosa works, however evidence suggests that it may have effects on neurotransmitter receptors in the brain and work as a selective oestrogen receptor modulator (SERM).

Several studies suggest that it may act on serotonin and opioid receptors which play a role in central nervous system processes that help govern body temperature(thermoregulation), and also feelings of stress, nervousness and mild anxiety. 3-5


The activity of Actaea racemosa in relation to oestrogen has also been investigated and the evidence suggests the Ze 450 extract in Femular/Femular Forte is likely to be non-oestrogenic.4,6


The research in this area suggests that Actaea racemosa may work instead as a selective oestrogen receptor modulator (SERM) helping to modulate and mimic oestrogen and is not likely to have a direct oestrogenic effect. 4,6   



Research on how Ze 450 extract works

Clinical studies on Ze 450 in Femular

Over 1000 women participated in clinical trials and studies, which demonstrated the beneficial effects of Ze 450 used exclusively in the Femular range. The research showed menopause symptom improvement as early as 1 month with increasing relief shown over 3 and 9 months. 7-9

Lopatka et al., 2007 7

541 women with menopausal complaints
studied over 4 months*

Significant improvement

vs. baseline (symptoms prior to study) for:

  • Menopausal symptoms after 4 months including: hot flushes and sweating, disturbed sleep, irritability, fatigue, mild anxiety, joint pain

Symptoms showed trends of  improvement as early as 1 month. 76% of patients judged efficacy to be 'good' or 'very good'.

Schellenberg et al., 2012 8

180 women with menopausal complaints
studied over 12 weeks**

Significant improvement

vs. placebo for:

  • Menopausal symptoms at 3 months: the greatest improvement was the reduction of hot flushes and sweating symptoms with high dose. A dose dependent effect of symptom relief demonstrated: A low dose** for mild symptoms and a high dose** for moderate to severe symptoms. For patients with severe symptoms, only the high dose provided relief.
Drewe et al. 2013 9

442 women with menopausal complaints
studied over 9 months^


vs. baseline (symptoms prior to study) for:

  • Relief of menopausal symptoms at 3 months, with high dose^ including: Hot flushes, sweating, disturbed sleep, nervous tension, temporary feelings of sadness, joint & muscular pain, headache

Treatment with high dose^ further improved symptoms beyond 3 months with significant relief seen at 9 months.

*Placebo, 6.5 mg of Ze 450 (low dose, 1 tablet of Femular) 

**Placebo, 6.5 mg of Ze 450 (low dose, 1 tablet of Femular) or 13 mg of Ze 450 (high dose, 2 tablets of Femular)

^13 mg Ze 450 per day for 3 months, followed by a further 6 months treatment with either 13 mg (high dose, 2 tablet of Femular or 1 tablet of Femular Forte) or 6.5 mg Ze 450 per day (low dose, 1 tablet of Femular).

These medicines may not be right for you. Read the warnings before purchase. These can be found in the recommended dosage and directions section on the Femular and Femular Forte web page. Follow the directions for use. If symptoms persist, worsen or change unexpectedly, talk to your health professional.

Flordis Difference

Femular with Ze 450 vs. Actaea racemosa  


There may be several products on the market labelled as containing a particular ingredient – such as Actaea racemosa. So what makes Femular with the specific Ze 450 extract of Actaea racemosa different?


Natural healthcare products containing Actaea racemosa can vary considerably depending on how they are produced. The specific Ze 450 extract used in the Femular range is produced using meticulous processes with careful consideration and control at every stage of growing, cultivation and production.


That means, you can be confident that the Femular product you are getting contains the same ingredient, processed in the precise way required that has demonstrated menopause symptom relief in clinical research. That’s the Flordis difference.

Femular with Ze 450: A Summary

Consistent quality

Rigorous processes, quality controls and extensive testing ensures that Femular with Ze 450 extract is the same as the medicine  tested in clinical trials to demonstrate menopause symptom relief.

Clinically Proven

Clinical research shows a trend towards improvement in symptoms after 1 month, with significant symptom relief at 3 months and at 9 months  7-9

Multiple menopause symptom relief

Including hot flushes, sweating, disturbed sleep, nervous tension & irritability 7-9

Well tolerated

Well-established tolerability based on clinical research and worldwide use. 

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Our source to patient philosophy

We make sure our natural medicines are consistent.


Not only do the clinical studies on our products demonstrate real health outcomes, they demonstrate the results you can expect from the same products you see on shelf. It’s all part of our Source to Patient philosophy.

See the steps taken to make our products


  1. Braun & Cohen, Herbs & Natural Supplements, 2005. Page 86
  2. Foster S. Black cohosh: Cimicifuga racemosa. A literature review. HerbalGram 1999;45:35–50
  3. Rhyu M-R et al., Agric Food Chem 2006; 54(26):9852-9857.
  4. Burdette JE, et al., J Agric Food Chem 2003; 51: 5661-5670.  Funded by NIH Grant P50 AT00155.
  5. Naumenko et al., Neuropharmacology 2011; 61 (8): 1360-136.
  6. Garita-Hernandez, M. et al., Planta Med 2006; 72: 317-323.
  7. Lopatka et al., J of Menopause 2007; 2:16-21.
  8. Schellenberg et al., Evidence-Based Comp and Alternative Med 2012.  Funded by Max Zeller Soehne AG.
  9. Drewe J et al., Phytomedicine 2013; 20:659-666.  Funded by Max Zeller Soehne AG.

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