Valerian offinalis and Humulus lupulus

What are Valerian and Hops?

Valeriana officinalis and Humulus lupulus are medicinal plants that work together to help relieve insomnia and sleeplessness

The history of Valeriana offinalis and Humulus lupulus use

Both Valerian offinalis and Humulus lupulus, have a long tradition of helping with insomnia and sleeplessness.

Valerian (Valeriana offcinalis) grows wild in forests, along river banks and on wet meadows throughout Germany. It is a tall upright perennial, to 1.5m with beautiful scented small reddish or white blossoms. Both the rhizome and roots are used in making medicinal extracts. Hops (Humuls lupulus) is a species of flowering plant native to Europe, western Asia and North America. It is a perennial, herbaceous, climbing plant which sends up new shoots in early spring and dies back to a cold-hardy rhizome in autumn.

The use of Valeriana offcinalis for insomnia stems from Ancient Greece, where it was known as ‘phu’ - a reference to the offensive odour of the roots. The Latin term valere, from which the common name Valerian originates, means "to be strong, be well”. The strobiles of female Humulus lupulus have been used for insomnia in European, Chinese, native North American and Ayurvedic traditional medicine for centuries.

The specific extract used by Flordis

The specific extract of Valerian offinalis and Humulus lupulus used by Flordis is known as Ze 91019.

Ze 91019 is extracted and formulated using a proven process. This individual and highly technical process ensures a consistent form and amount of Ze 91019 is used in every formulation - meaning each final product will contain the same high quality active ingredient.

Natural medicines can vary considerably depending on how they are produced. Flordis believes it’s the science behind growing, harvesting and processing that delivers the true health benefits of natural medicine. That’s why in the making of a Flordis medicine, careful attention is applied to plant species and growing methods through to cultivation and harvest, using precise processes to help produce consistent crops. This is continued with extracting and manufacturing of specific ingredients following a series of strict controls to help deliver a consistent medicine from one batch to the next.

It is this specific medicine that is tested in clinical trials. And it’s the same medicine that you receive, which is one of the reasons you can feel good about its effectiveness. Flordis medicines follow processes where all of the steps involved in the growth and manufacture of the natural medicine are tightly controlled to reduce variability and to help ensure consistency.

Ze 91019 has been well researched and has demonstrated good results in clinical trials and other scientific research.

In an observational study, three times more patients slept through at night without waking, or woke only once, after taking Ze 91019 for 4-6 weeks.4

The seed to patient journey

The specific extract Ze 91019 contains, whole herb extracts of Valerian and Hops made in Switzerland.  The process of manufacture is as follows:

  • The specific species of herb is selected
  • Standardised cultivation and harvesting occurs (helping to ensure a consistent phytochemical profile) - followed by harvesting, drying and processing
  • A series of strict controls are applied to the manufacturing processes - including everything from solvents and extraction methods through to packaging, storage and transportation of the final product - helping to ensure that every single product is consistent (we refer to this as “batch to batch consistency”)
  • Where possible, research and clinical studies are conducted on the finished product to validate its tolerability and efficacy

How it works

Ze 91019 acts by positively affecting the two body systems that regulate sleep: the circadian rhythm, which regulates our sleep and wake times, and the homeostatic process, which tells us exactly when it’s time for sleep and helps us maintain sleep throughout the night.1,2

Key studies on Ze 91019

Ze 91019 has been studied for a decade, in many clinical trials and scientific research. Research has suggested Ze 91019 is associated with the following benefits:

  • Helping to reduce total awake time and improved sleep efficiency  (ratio of true sleep time vs time spent in bed) in a randomised placebo-controlled trial of 30 adults3.  Four out of 5 patients reported waking refreshed after 2 weeks of taking Ze 91019 - and this effect was noticed for a further 4 weeks3
  • In an observational study, three times more patients slept through at night without waking, or woke only once, after taking Ze 91019 for 4-6 weeks.4
  • In another study patients took significantly less time to fall asleep when taking Ze 91019 compared to placebo.5

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 1. Mueller CE et al Life Sciences 2002; 71(16):1939 – 1949. 2. Abourashed, E.A. et al.Phytomedicine 2004; 11: 633-38. 3. Fussel A, et al. Eur J Med Res. 2000;5:385-90. 4. Lataster MJ, et al. Notabene Medici 1996;4,:182-5.7. 5. Koetter U et al Phytother Res 2007; 21(9):847-851.