Hypericum perforatum (St. John's wort)

What is Hypericum perforatum?

Hypericum perforatum is more commonly known as St John’s wort, a plant that has been popularly used for centuries to relieve mild anxiety, stress and nervous tension. Scientists believe the shrubby plant, which has clusters of yellow flowers with oval, elongated petals, is native to Europe, parts of Asia and Africa and the western United States. Both the flowers and leaves are used as medicine.

The history of Hypericum perforatum use

St John's wort has been used since the middle ages to help manage symptoms of mild anxiety and stress. It was the ancient Greek herbalists, such as Hippocrates, who originally documented the medicinal uses of St John’s wort. Hypericum perforatum was used by Roman military doctors and in the middle ages was a common ingredient in herbal ‘potions’. It is believed to be called St John’s wort because it flowers around St John’s Day (June 24th) in the Northern hemisphere.

The specific extract used by Flordis

The Flordis extract of St John’s wort is known as Ze 117 and has been shown to assist in the relief of nervous tension, stress and mild anxiety in a number of published clinical trials. Flordis uses a specially patented production process to carefully derive the Ze 117 ingredient, helping to ensure a reliable, high quality product that is consistent from one batch to another. This care in producing consistent quality actives means that you can expect consistent clinical outcomes.1

Scientific studies suggest that Ze 117 inhibits the re-uptake of noradrenaline, serotonin and dopamine. These neurotransmitters have a range of effects in the body.

Neurotransmitters that are likely to be affected by Ze 117 include:

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How it works

The whole plant extract is considered to be responsible for the therapeutic actions of St John’s wort.

Scientific studies suggest that Ze 117 works indirectly on chemicals in the brain such as serotonin, dopamine, and noraderenaline that are linked with stress, tension and anxiety. 2,3

Key studies on Ze 117

The effects of Ze 117 have been studied in over 2,000 people, including a one-year study that showed that it was well tolerated and demonstrated continued improvement of symptoms during this time. 4

Ze 117 has been shown to significantly improve symptoms associated with mild anxiety and stress4,5,6,7 with good tolerability. 4,5

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1. Wurglics M, et al. J Am Pharm Assoc. 2001;41(4):560-566. 2. Holsboer-Trachsler and Vanoni. Depression in der Praxis. 3. Auflage. 2007. 88-89. 3. Rang HP, et al. Pharmacology, 3rd Edition. 1995. pp. 492-502. 4. Woelk H, et al. BMJ. 2000;21:536-9. 5. Schrader E. Int Clin Psychopharma. 2000;16:277-283. 6. Schrader E, et al. Human Psychopharmacology. 1998;13:163-169. 7 Brattström A. J Phymed. 2009;16:277-283.