Alpha-Cyclodextrin (FBCx)

What is Alpha-cyclodextrin ?

Alpha-cyclodextrin is a dietary fibre derived from corn. In Australia a patented version of alpha-cyclodextrin is known as FBCx®.  FBCx is an abbreviation for “Fat Binding Complexer”.

This innovative fibre binds to dietary fat, helping to reduce up to 54g (2036 kJ/486 Cals) of dietary fat from being absorbed by the body each day. By reducing the amount of dietary fat absorbed in the body, FBCx helps to maintain healthy cholesterol and triglyceride levels (triglycerides are a type of fat found in your blood, also known as blood lipids).

This innovative fibre binds to dietary fat, helping to reduce up to 54g (2036 kJ/486 Cals) of dietary fat from being absorbed by the body each day.1

The history of Alpha-cyclodextrin use

Alpha-cyclodextrin’s fat binding effect was discovered nearly a decade ago by researchers at Wayne State University in America. Pre-clinical studies 2,3 identified that 1 gram of alpha-cyclodextrin is able to bind and eliminate up to 9 grams of dietary fat.

These trials paved the way for further research, including a preclinical study4 suggesting that alpha-cyclodextrin may have a greater binding affinity for saturated fats and trans fatty acids.

Key studies on FBCx

Over the last 10 years, research has established the supportive effects of FBCx on blood cholesterol and triglyceride level management within the normal range. 

The most recent clinical studies on FBCx are:

  • The Beneficial Effects α-Cyclodextrin on BloodLipids and Weight Loss in Healthy Humans Comerford KB, et al. Obesity 2011;19:1200-1204.
  • The Effect of α-Cyclodextrin on postprandial lipid and glycemic responses to a fat-containing meal, Jarosz PA, et al. Metabolism 2013;62(10):1443-7 3.

How it works

When taken with a fatty meal or snack, FBCX (alpha-cyclodextrin) binds (attaches) to dietary fats (fats in foods consumed in the diet). This forms a complex which is then passed naturally through the bowel, helping to prevent the fat from being digested and absorbed.

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References

1. Jen KL et al Nutr Diet Suppl 2013;5:1-7.  2. Wagner EM, et al. Metab. Clin. Expt2008;57:1046-1051.  3. Artiss JD, et al.. Metab Clin a Experimental 2006;55:195-202.  4. Gallaher DD, et al. Fed Am Soc for Exp Bio Jnl 2007;21:A730.  5. Comerford KB, et al. Obesity 2011;19:1200-1204.  6. Jarosz PA, et al. Metabolism 2013;62(10):1443-7 3.