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Legalon ® (MZ 80)

Silybum marianum (Milk thistle)

To improve and maintain:

Liver health

Legalon helps to maintain healthy liver function

Legalon® (MZ 80) has been shown to help maintain healthy liver function.1-3 Legalon contains the patented extract of Silybum marianum (Milk thistle) that was developed by the German herbal medicine manufacturer Madaus in 1968. It is a benchmark product and the majority of published clinical research on silymarin has used Legalon.

What is Legalon used for?

Legalon has been shown in clinical trials to support healthy liver function.

Clinical trials have demonstrated that Legalon supports liver health by:

  • Inhibiting the activation of inflammatory cells4,6,7
  • Inhibiting oxidative stress5
  • Inhibiting the activation of hepatic stellate cells that cause fibrosis6,8
  • Aids renewal of normal healthy liver cells5

Safety & efficacy

Legalon capsules are well tolerated with no known drug interactions.4 Legalon has demonstrated positive results in a number of large-scale studies – including one involving over 2000 participants1 – with a very low incidence of side effects. Follow up safety data has shown that ongoing administration can be of continued benefit, following patients taking Legalon for up to six years.3

Legalon's unique formulation

Legalon contains a specific extract of Silybum marianum (MZ 80) that has been used in numerous clinical trials and is the benchmark silymarin product worldwide. Legalon capsules are produced using a patented process, resulting in a standardised product with excellent bioavailability.

Legalon is clinically proven, it is the exact product that has been used in numerous clinical trials. This is very important for natural medicines as there can be great variance between products, even if they appear to use the same active ingredients, due to the part of the plant that is used, as well as the growing, harvesting and production conditions & methods. The outcomes of clinical studies for natural medicines should therefore only apply to the exact product that has been tested. As a result, other products containing silymarin may not deliver the same results that Legalon has demonstrated in the research.

Directions & dosage

Adults and adolescents 12 years and over: 1 capsule three times a day

Once the desired therapeutic outcome is achieved, the dose may be reduced to 1 capsule twice daily for maintenance.

Always read the label. Use only as directed. If symptoms persist, or the condition recurs, it is important to speak with a healthcare professional.

Frequently asked questions

Legalon is clinically proven, it is the exact product that has been used in numerous clinical trials. This is very important for natural medicine as there can be great variance between products, even if they appear to use the same active ingredients, due to the plant that is used, growing methods, harvesting processes and manufacturing methods. The outcomes of clinical studies for natural medicines may therefore only apply to the exact product that has been tested. As a result, other products containing Milk thistle cannot be expected to deliver the same results that Legalon has demonstrated in the research.

Legalon can be taken on an empty stomach; this has the advantage of allowing the active agent, silymarin, to be more quickly absorbed into the body – therefore acting more rapidly and effectively. However, if you are experiencing any gastrointestinal problems, Legalon can be taken during or after meals.

Legalon is not recommended during pregnancy or lactation as there are no published studies to establish its safe use during pregnancy or while breastfeeding.

Where appropriate, Legalon can be prescribed for adolescents 12 years and older. If you have specific questions or concerns, it is important to speak with a healthcare professional.

Legalon is generally very well tolerated and no serious side effects have been recorded. In rare cases, a mild laxative action has been observed after taking Legalon. It is important to speak with a healthcare professional if you are concerned about possible side effects.

There are no known interactions between Legalon and other medications.5 If you are concerned about taking Legalon with any prescription medications, it is important to speak with a healthcare professional.

Yes, Legalon is gluten free

No, Legalon does not contain lactose.

Legalon capsules have no known adverse effects in these situations.

Legalon is available from naturopaths, selected health food stores and pharmacies. If you go to the Where to buy button above and follow the instructions, you will be able to find a list of practitioners, health food stores and pharmacies in your area who either stock Legalon or will know how to order Legalon. Even if your local pharmacy is not on the list, they will be able to order it in for you.

References

1. Albrecht M et al Z Klin Med (1992) 47 (2): 87-92. 2. Salmi H & Sarna S. Scand J Gastroenterology 1982; 17: 517-21. 3. Ferenci P et al J Hepatology 1989; 9: 105-13 4. Butorova L, et al. Exp Clin Gastroenterol. 2010;3:85-91 5. Saller R et al Drugs 2001; 61 (14): 2035-63 6. Dehmlow C et al Hepatology 1996; 23: 749-54 7. Trappoliere M, et al. Journal of Hepatology. 2009;50:1102–1111 8. Feher J, et al. Orvosi Hetilab. 1989;130:2723-2727. 9. Doehmer J, et al. Toxicology in Vitro. 2008; 22:610-617
Some of this research was conducted using funding provided by Rottapharm/Madaus, manufacturer of Legalon.

Where to buy

Flordis encourages you to discuss your health needs with your doctor, naturopath or pharmacist.

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Always read the label. Use only as directed. If symptoms persist, consult your healthcare professional.